Development and Evaluation of Gastroretentive Floating Matrix Tablets of Quetiapine Fumarate

A Francis Raj; A Nandhini; P Manikandan; K Christin Selvaraj

A Francis Raj Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India
A Nandhini Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India
P Manikandan Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India
K Christin Selvaraj Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India

Keywords: Buoyancy,, Gastroretentive floating matrix tablets,, In vitro release,, In vivo study,, Quetiapine fumarate,, Swelling

Abstract

Introduction: The present study was carried out to evaluate gastroretentive floating matrix tablets of Quetiapine Fumarate
(QFR) to reduce the dose frequency and higher bioavailability.
Materials and Methods: Floating matrix tablets of QFR were prepared by employing gel-forming polymers such as hydroxypropyl
methylcellulose (HPMC) (K100M, K15M), methyl cellulose (MC), and xanthan gum (XG). The formulations were evaluated for
various physicochemical characteristics (weight, thickness, hardness, and diameter), drug and polymers compatibility, in vitro
buoyancy, swelling index (SI), in vitro drug release characterization, and in vivo X-ray studies.
Results: The differential scanning calorimetry studies revealed no interaction between the drug and polymers. All the
physicochemical properties of the developed formulations were found within the specified limits. Formulation containing HPMC
K100M and a higher concentration of MC floated immediately, followed by formulations with HPMC K15M. The SI was directly
associated with polymers concentrations (HPMC K100M, HPMC K15M and XG). The in vitro release studies showed that the
formulation F1 (HPMC K100M 80%) sustained the drug release (101.01%) for about 12 h. All the formulations followed zeroorder
kinetics and non-Fickian diffusion mechanism. In vivo X-ray studies of the selected formulation F1 (HPMC K100M 80%)
showed gastric retention time of about 12 h.
Conclusion: The present study results indicated a successful approach to achieve controlled release of QFR in the stomach
for 12 h. Further studies can be pursued to confirm improve the bioavailability of the QFR from the present formulation

Author Biographies

A Francis Raj, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India

Bio-Statistician, Department of Statistics

A Nandhini, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India

Clinical Pharmacist, Department of Clinical Pharmacy

P Manikandan, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India

Clinical Pharmacist, Department of Clinical Pharmacy

K Christin Selvaraj, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Tamil Nadu, India

Lecturer, Department of Community Medicine

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