A Study of Cognitive Impairment in Patients with Type 2 Diabetes Mellitus – A Prospective Observational Study`

  • V B Sarath Puducherry, India,
  • P V Balaji Puducherry, India
Keywords: Cognition, Mini-mental status examination score, Type 2 diabetes mellitus


Introduction: Type 2 diabetes mellitus (DM) is the most lifestyle risk factor for cognition. Regular treatment and management of Type 2 DM could prevent the onset and progression of cognitive impairment. Cognitive decline associated with DM may influence one’s ability to perform self-care and affect glycemic control.
Aim: Our prospective observational study aimed to analyze the cognitive impairment using a mini-mental status examination (MMSE) in patients with Type 2 DM.
Materials and Methods: This prospective observational study was conducted to analyze the cognitive impairment using MMSE in patients with Type 2 DM. A total of 50 patients diagnosed with Type 2 diabetes were included in the study. All the demographic and laboratory investigation data so obtained was tabulated and was analyzed statistically, and results were discussed.
Results: Of 50 patients, 26 patients were male and 24 patients were female. Based on the age group, 11 patients were in the age group below 40 years, 21 patients between 40 and 50 years, 16 patients between 51 and 60 years, and 2 patients >60 years. Based on the duration of Type 2 diabetes, 16 patients had <5 years and MMSE score of 24.28 and 34 patients had >5 years and MMSE score of 22.14. Based on cognitive impairment, 44 patients had mild cognitive impairment and 6 patients had moderate cognitive impairment.
Conclusion: From this study, we concluded that the duration of Type 2 DM and level of HbA1c affect the cognitive status of the individuals. A greater understanding of the mechanisms linking Type 2 DM and cognitive impairment may facilitate the development of new ways for the treatment of cognitive impairment.

Author Biographies

V B Sarath, Puducherry, India,

1Associate Professor, Department of Physiology, Vinayaka Mission’s Medical College, Vinayaka Mission’s Research Foundation (Deemed to be University), Karaikal, 

P V Balaji, Puducherry, India

2Professor, Department of Physiology, Vinayaka Mission’s Medical College, Vinayaka Mission’s Research Foundation (Deemed to be University), Karaikal, 


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