Development and Evaluation of Gastroretentive Floating Matrix Tablets of Quetiapine Fumarate
Introduction: The present study was carried out to evaluate gastroretentive floating matrix tablets of Quetiapine Fumarate
(QFR) to reduce the dose frequency and higher bioavailability.
Materials and Methods: Floating matrix tablets of QFR were prepared by employing gel-forming polymers such as hydroxypropyl
methylcellulose (HPMC) (K100M, K15M), methyl cellulose (MC), and xanthan gum (XG). The formulations were evaluated for
various physicochemical characteristics (weight, thickness, hardness, and diameter), drug and polymers compatibility, in vitro
buoyancy, swelling index (SI), in vitro drug release characterization, and in vivo X-ray studies.
Results: The differential scanning calorimetry studies revealed no interaction between the drug and polymers. All the
physicochemical properties of the developed formulations were found within the specified limits. Formulation containing HPMC
K100M and a higher concentration of MC floated immediately, followed by formulations with HPMC K15M. The SI was directly
associated with polymers concentrations (HPMC K100M, HPMC K15M and XG). The in vitro release studies showed that the
formulation F1 (HPMC K100M 80%) sustained the drug release (101.01%) for about 12 h. All the formulations followed zeroorder
kinetics and non-Fickian diffusion mechanism. In vivo X-ray studies of the selected formulation F1 (HPMC K100M 80%)
showed gastric retention time of about 12 h.
Conclusion: The present study results indicated a successful approach to achieve controlled release of QFR in the stomach
for 12 h. Further studies can be pursued to confirm improve the bioavailability of the QFR from the present formulation
floating matrix tablets of perindopril erbumine. Indian Pharm
2. Kasper S, Müller-Spahn F. Review of quetiapine and its clinical applications
in schizophrenia. Expert Opin Pharmacother 2000;1:783-801.
3. Rani BS, Reddy AB, Tony DE, Raja DS, Sindhura L, Kumar NS.
Aceclofenac floating tablets-a promising sustained release dosage form. Int
J Drug Dev Res 2011;3:290-300.
4. Kristl J, Baumgartner S, Vrecer F. Optimization of floating matrix tablets
and their gastric residence time. Int J Pharm 2000;195:125-35.
5. Saravanan D, Padmavathy J, Rajesh D. Formulation and evaluation of
Ofloxacin floating talbets using HPMC. Int J Pharm Pharm 2011;3:170-3.
6. Srikanth MV, Rao NS, Sunil SA, Ram BJ, Kolapalli VR. Statistical design
and evaluation of a propranolol HCL gastric floating tablet. Acta Pharm Sin
7. Kachrimanis K, Barmpalexis P, Geogarakis E. Solid dispersions in the
development of a nimodipine floating tablet formulation and optimization
by artificial neural networks and genetic programming. Eur J Pharm Bio
8. Shivkumar G, Kenganora M. Formulation and development of
hydrodynamically balanced system for aceclofenac. Indo Global Res Lib
9. Charyulu RN, Patil BA, Deepika CH, Prabhu P, Shastry CS. Development
of gastro retentive floating matrix tablets of diltiazem hydrochloride. Nitte
Univ J Health Sci 2011;1:38-45.
10. Nasa P, Mahant S, Sharma D. Floating systems: A novel approach towards
gastroretentive drug delivery systems. Int J Pharm Pharm Sci 2010;2:2-7.
11. Borkar SN, Suresh R, Sawant VA, Shende VS, Mokale VJ, Dama G. An
approach to formulate bilayered gastro retentive floating drug delivery
system of cefpodoxime proxetil. Int J Chem Tech Res 2010;2:1229-42.
12. Mayur NJ, Shanmugam S, Sundaramoorthy K, Ayyappan T, Vetrichelvan T.
Formulation and in vitro evaluation of gastro retentive floating matrix
tablets of famotidine. Int J Pharma Bio Sci 2010;4:548-60.
13. Tadros MI. Controlled-release effervescent floating matrix tablets of
ciprofloxacin hydrochloride: Development, optimization and in vitro-in vivo
evaluation in healthy human volunteers. Eur J Pharm Sci 2010;74:332-9.
14. Havaldar VD, Kulkarni AS, Dias RJ, Aloorkar NH, Mail KK. Floating
matrix tablets of atenolol: Formulation and in vitro evaluation. Asian J
15. Paudel P, Bhatta P, Lamichhane S. Influence of different grades and
concentrations of hydroxypropyl methyl cellulose on the release of
metformin hydrochloride. World J Pharm Sci 2014;2:966-80.
16. Dalvadi HP, Shah DP, Sonani NG, Patel JK, Patel AB. Design and evaluation
of Gastroretentive tablets of atenolol using HPMC polymer. Eur Parenteral
Pharm Sci 2011;16:85-92