Serum Albumin and Uric Acid Estimation in Ischemic Heart Disease Patients

  • P Kughapriya Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu, India,
  • J A Elanchezhian Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu,India
Keywords: Hyperuricemia, Hypoalbuminemia, Ischemic heart disease, Oncotic pressure, Semi Auto Analyzer

Abstract

Aim: The aim of the study was to evaluate serum uric acid and serum albumin levels in ischemic heart disease patients (IHD).
Materials and Methods: Around 60 persons were recruited for the study, with 30 patients diagnosed as IHD and 30 healthy
volunteers. Serum uric acid and serum albumin were estimated using Semi Auto Analyzer. Statistical analysis was performed
using SPSS version 16. The parameters were compared among two groups using independent t-test.
Results: Serum uric acid levels (P = 0.000) were increased significantly in Group II patients compared to those in Group I
controls. There was no significant difference in serum albumin levels among the two groups. Levels of serum albumin in Group I
and Group II are almost similar.
Conclusion: From this study, serum uric acid can be used to assess the prognosis of patients with IHD. Our study showed a
normal serum albumin levels in both the groups, but low serum albumin is associated with high mortality in general.
Clinical significance: Recent studies have provided evidence that uric acid may play a role in the progression of various diseases
including cardiovascular complications. As a result, the measurement of uric acid concentrations is now mandatory for the management
of those disease states. Low serum albumin level causes subclinical fluid overload in IHD patients leading to poor prognosis. Hence,
further studies have to be carried out to assess the association of quality of life in IHD patients and serum albumin levels.

Author Biographies

P Kughapriya, Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu, India,

Assistant Professor, Department of Biochemistry,

J A Elanchezhian, Government Mohan Kumaramangalam Medical College Hospital, Salem, Tamil Nadu,India

Associate Professor, Department of General Medicine,

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Published
2018-06-15